Elucidation of the regulatory role of the fructose operon reveals a novel target for enhancing the NADPH supply inCorynebacterium glutamicum

A new paper in project 4 has recently been published in Metabolic Engineering.

In the paper a novel and important role of the fructose operon in regulating sugar metabolism is disclosed. A model proposing how sugar phosphates govern sucrose metabolism is presented. The NADPH supply on sucrose is boosted through metabolic rerouting.
Impressively the highest lysine yield ever obtained on fructose is achieved with minimal genetic manipulation.

Read the paper below.